The present invention describes a process of production of a live attenuated vaccine against sheep pox virus (SPV). The process disclosed in the present invention involves adaptation and modification i. e. further attenuation of the virus in Vero cell line. The vaccine composition produced by the process disclosed in the present invention has been shown to be safe and protected sheep on virulent challenge. The present invention also provides a process for immunizing a subject using the vaccine composition disclosed.
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