首页> 外国专利> PHARMACEUTICAL COMPOSITIONS OF ENTACAPONE, LEVODOPA AND CARBIDOPA WITH IMPROVED BIOAVAILABILITY.

PHARMACEUTICAL COMPOSITIONS OF ENTACAPONE, LEVODOPA AND CARBIDOPA WITH IMPROVED BIOAVAILABILITY.

机译：恩他卡朋，左旋多巴和卡比多巴的药物成分具有改善的生物利用度。

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摘要

The present invention relates to single oral dose pharmaceutical compositions comprising a combination of entacapone, levodopa and carbidopa, or salts thereof along with one or more sugar alcohols, wherein the entacapone is co-micronized with one or more sugar alcohols. The composition of the invention exhibits bioequivalence to commercially available entacapone, levodopa and carbidopa combination formulation marketed under the trade name Stalevo200supÂ®/sup. The invention also relates to processes for making such compositions.

机译：本发明涉及包含恩他卡朋，左旋多巴和卡比多巴或其盐与一种或多种糖醇的组合的单次口服药物组合物，其中所述恩卡他朋与一种或多种糖醇共微粉化。本发明的组合物表现出与以商品名Stalevo200 出售的市售的恩他卡朋，左旋多巴和卡比多巴组合制剂具有生物等效性。本发明还涉及制备这种组合物的方法。

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公开/公告号MX2010008711A

专利类型
公开/公告日2011-05-03

原文格式PDF
申请/专利权人 WOCKHARDT LIMITED;
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申请/专利号MX20100008711
发明设计人 GIRISH KUMAR JAIN;RITESH KAPOOR;MUNISH TALWAR;MANOJ MASHALKAR;
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申请日2009-02-06
分类号A61K31/275;A61K9/14;A61K9/16;A61K9/26;A61K31/195;A61K31/198;A61K47/26;
国家 MX
入库时间 2022-08-21 18:05:27

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