SCREENING METHOD, PROCESS FOR PURIFYING OF NON-DIFFUSIBLE ABETA OLIGOMER, SELECTIVE ANTIBODIES AGAINST SAID NON-DIFFUSIBLE ABETA OLIGOMERS AND A PROCESS FOR MANUFACTURING OF SAID ANTIBODIES

摘要

Provided is a method of detecting auto-antibodies having specificity for non-diffusible globular A beta (X - 38 to 43) oligomer structure epitope in a sample derived from a subject, which method comprises contacting the sample with non-diffusible globular A beta (X - 38 to 43) oligomer or a labelled or cross-linked derivative thereof, wherein X is selected from the group consisting of the numbers 1 to 24, and detecting a complex formed by the antibody and the oligomer or derivative, the presence of the complex indicating the presence of the auto-antibodies.