Hepatitis B virus vaccine comprising a hepatitis B virus surface antigen, aluminium phosphate, 3-O-deacylated monophosphoryl lipid A and a triethylammonium ion

摘要

Disclosed is a hepatitis B virus vaccine comprising a hepatitis B virus surface antigen (HBsAg), an adjuvant composition comprising aluminium phosphate and 3-0-deacylated monophosphoryl lipid A such that at least 50% of the 3-0-deacylated monophosphoryl lipid A is adsorbed to the aluminium phosphate, and a triethylammonium ion. The triethylammonium ion solubilizes the 3-0-deacylated monophosphoryl lipid A in said vaccine.