New isothiazoloquinolones and related compounds as anti-infective agents

摘要

Disclosed are 9-cyclopropyl-isothiazolo[5,4-b]quinoline-3,4(2H,9H)-diones and 9-cyclopropyl-isothiazolo[1,8]naphthyridine-3,4(2H,9H)-diones having formula I, which are useful for the manufacture of a medicament for treating a bacterial or protozoal infection such as a urinary tract infection, pyelonephritis, lower respiratory tract infection, skin infection, skin-structure infection, urethral gonococcal infection, cervical gonococcal infection, urethral chlamydial infection, cervical chlamydial infection, bone infection, joint infection, gram-negative bacterial infection, infectious diarrhoea, typhoid fever, prostatitis, acute sinusitis, acute exacerbation of chronic bronchitis, pneumonia, intra-abdominal infection, gynecologic or pelvic infection.