Compositions and methods for the reduction of post-operative pain

摘要

Disclosed is an anhydrous body-absorbable mechanically hemostatic putty composition comprising in intimate admixture the following Components 1,2, and 3: Component 1: a finely powdered carboxylic acid salt having a carboxylate anion and a metallic cation; Component 2: an anhydrous organic liquid comprising (a) a tocopherol selected from the group consisting of tocopherol, an aliphatic monocarboxylic acid ester of tocopherol, a polycarboxylic acid ester of tocopherol, and mixtures thereof, and (b) a block copolymer of ethylene oxide and propylene oxide, and Component 3: a free base form of an analgesic, wherein Component 2 makes up 20-60 percent of the composition by weight. Also disclosed is a package comprising said composition and the use of said composition for the treatment of bone bleeding and pain associated with bone.