Thiophenyl and pyrrolyl azepines as serotonin 5-HT2C receptor ligands and uses thereof

摘要

Disclosed is a fused thiaphene azacycloheptane compound of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I0 include: (R,S)-1-Trifluoromethyl-1,2,3,4,5,6,7,8-octahydro-9-thia-6-azacyclopenta[a]azulene; (R,S)-3,3-Dimethyl-1-trifluoromethyl-1,2,3,4,5,6,7,8-octahydro-9-thia-6-azacyclopenta[a]azulene; 4-Methyl-1-trifluoromethyl-1,2,3,4,5,6,7,8-octahydro-9-thia-6-azacyclopenta[a]azulene; and 3,3,4-Trimethyl-1-trifluoromethyl-1,2,3,4,5,6,7,8-octahydro-9-thia-6-azacyclopenta[a]azulene. Also disclosed is a pharmaceutical composition of comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament to the treatment of a disease wherein modulation of a 5-HT2c function is desired.