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Procedure for amending the formation of a Crystal of mycophenolic acid and mycophenolate
Procedure for amending the formation of a Crystal of mycophenolic acid and mycophenolate
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机译:修改霉酚酸和霉酚酸酯晶体形成的程序
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摘要
Such a procedure for modifying a Crystal of acicular Drug comprising discontinue the drug in a Crystalline System Solvent methanol / water at a ratio of between 90 and 98: 2: 10 and subject to suspension Oscillation of temperature in zigzag form, where the Drug Is acicular Salt mycophenolate sodiumThe maximum and minimum temperature Oscillation is 42 to 47u00bac + / - 40 to 7 degrees C, the Oscillation period is 110 to 160 minutes, the number of oscillations is 6 to 16 and optionally applies agitation
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