Derivatives of N - bencensulfonamida - 3.4 - diamino - 3 - substituted cyclobutene 1,2 Dione - - as antagonists of chemokine receptor CXCR2

摘要

Refers to bencen sulfonamide compounds of formula (i) wherein R1 is H, carbociclico (C3 - C10) (C1 - C6 alkyl, optionally substituted by Halogen), cn or Oh, among others; R2 is carbociclico (C3 - (C1 - C10), alkyl, alkoxyl (C1 - C6) optionally substituted C6), among others; R3 is H, haloge No or NC; R4 is H, alkyl, cycloalkyl (C1 C8) (C3, C8), among others; R5 is alkyl (C8, C1)Cycloalkyl (C3, C8) cicloalquenilo (C5 - C8), among others, is cr14 X or n, where R14 is H or alkyl (C1 - C6).Preferred compounds are: 6 - Chloro - 3 - [4 - [2 - ((R) - 1 - phenyl propyl amino) - ciclobut enil - amino] - 1 - hydroxy - 2 - methoxy - N - N - methyl - bencen sulfonamide, 6 - Chloro - hydroxy - 2 - N - N - Methyl - 3 - methoxy - {2 - [(R) - 1 - (2 - methyl - 5 - furan - yl) - propyl] - 4 - amino - ciclobut [- 1 - il - bencen sulfonamide amino} - 3, 6 - Chloro - {3,4 - [2 - [(S) - tetrahydro - thiophene-3 - yl) - amino] - ciclobut - il - 1 - amino) - 2-hydroxy-n - methoxy - N - methyl - bencen sulfonamide, among others. Also refers to a method of Preparation. These compounds are antagonists of chemokine receptor CXCR2 being useful in the treatment of chronic obstructive pulmonary disease, ovarian cancer, emphysema, pulmonary fibrosis