THE USE OF AMPAKINES AND OTHER MODULATORS OF IONOTROPIC GLUTAMATE RECEPTORS IN THE PRODUCTION OF NEW NEURONS DERIVED FROM NEURAL STEM CELLS.

摘要

The present invention relates to the method of culture of the plasma cells based on the use of the amphiphiles and / or other modulators of glutamatergic Ionotrophic receptors. THESE COMPOUNDS INDUCE A STRONG PROLIFERATIVE AND PRONEUROGENIC ACTION AND AN EFFECT ON NEURONAL DIFFERENTIATION WHEN APPLIED TO SVZ CULTURES. In another aspect of the present invention, compositions based on the ampacins and / or other modulators of glutamatergic Ionotrophic receptors are described for use as inducers of neuron production and / or diffusion when applied to SVZ cultures. Furthermore, the present invention also relates to compositions comprising cDNAs of plasma cells treated with amphiphiles and / or other modulators of Ionotrophic glutamatergic receptors and their use as medicament for the treatment, prevention and / or enhancement of conditions of the central nerve system (CNS), such as CEREBRAL DISEASES AND / OR NON-PATHOLOGICAL CEREBRAL CONDITIONS. The present invention is applicable in the pharmaceutical and medical fields.