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NANOPARTICLES OF PROTEIN WITH COUPLED APOLIPOPROTEIN E FOR OVERLINING THE BLOOD BRAIN BARRIER AND METHOD FOR THE PRODUCTION THEREOF

机译：覆盖血脑屏障的蛋白与纳米蛋白结合的纳米颗粒及其制备方法

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摘要

The present invention relates to nanoparticles for penetrating the blood-brain barrier. The nanoparticles are characterized in that they consist of a hydrophile protein or of a combination of hydrophile proteins, preferably of serum albumin, with particular preference of human origin, to which apolipoprotein E is coupled. The invention further relates to processes for the manufacture of such nanoparticles.

机译：本发明涉及用于穿透血脑屏障的纳米颗粒。纳米颗粒的特征在于它们由亲水蛋白或亲水蛋白的组合组成，优选地由血清白蛋白组成，其中载脂蛋白E特别优选为人源。本发明进一步涉及用于制造这种纳米颗粒的方法。

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公开/公告号AT511833T

专利类型
公开/公告日2011-06-15

原文格式PDF
申请/专利权人 LTS LOHMANN THERAPIE-SYSTEME AG;
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申请/专利号AT20020738009T
发明设计人 KREUTER JOERG;LANGER KLAUS;WEBER CAROLIN;ALYAUTDIN RENAD;
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申请日2002-04-30
分类号A61K9/51;A61K47/42;A61K9/14;A61K9/26;A61K31/197;A61K31/4375;A61K31/451;A61K31/4741;A61K31/704;A61K38/08;A61K47/08;A61K47/18;A61K47/20;A61K47/48;A61P25/04;A61P25/28;A61P35;A61P43;
国家 AT
入库时间 2022-08-21 18:03:14

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