conformationally constrained peptides that bind to the ORL-1 receptor.

摘要

Ligand ORL-1 receptor, comprising an address segment C-terminal ligand nociceptin (NC) native, having the amino acid sequence of SEQ ID NO: 3, which address segment having been modified by replacing one or more amino acid residues with one or more amino acids promoters helices & 945; (X & 945;) or with one or more promoting amino acid analogs helices & 945; (X & 945;), wherein the at least one amino acid analog is AIB, wherein the address segment comprises a sequence selected from the group consisting of: (X & 945;) - RKS-A-RKL-A-NQ ( SEQ ID NO: 4); A-RKS- (X & 945;) - RKL-A-NQ (SEQ ID NO: 5); A-RKS-A-RKL- (X & 945;) - NQ (SEQ ID NO: 6); (X & 945;) - RKS- (X & 945;) - RKL-A-NQ (SEQ ID NO: 7); (X & 945;) - RKS-A-RKL- (X & 945;) - NQ (SEQ ID NO: 8); A-RKS- (X & 945;) - RKL- (X & 945;) - NQ (SEQ ID NO: 9); and (X & 945;) - RKS- (X & 945;) - RKL- (X & 945;) - NQ (SEQ ID NO: 10); wherein the ligand further comprises an N-terminal segment of a native NC ligand, and salts and solvates pharmaceutically acceptable same message.