anticarcinogenic to kinase inhibitors epidermal growth factor receptor response predictive biomarkers.

摘要

An in vitro method for predicting the sensitivity of tumor growth to inhibition by an EGFR kinase inhibitor, comprising cells: assessing the level of an epithelial biomarker expressed by a tumor cell; assessing the level of a mesenchymal biomarker expressed by a tumor cell; and predicting the sensitivity of development of tumor inhibition cells by an inhibitor of EGFR kinase, wherein a high ratio of expression levels of epithelial to mesenchymal biomarker correlates with high sensitivity to inhibition by inhibitors EGFR kinase.