Peptide YY (PYY) for metabolic disorders of glucose.

摘要

An in vitro method for inducing, enhancing, restore or maintain glucose responsiveness of cells or islets comprising contacting cells or islets with a peptide YY (PYY peptide), wherein the PYY peptide causes maturation of islets insensitive to glucose mature islets that respond to glucose by releasing insulin, and wherein the PYY peptide is selected from: i) encoded by a nucleic acid sequence which hybridizes under stringent condition peptide, including a washing step with 0, 2X SSC at 65 ° C, with SEQ ID NO: 1, ii) a peptide consisting of an amino acid sequence at least identical 70% to SEQ ID NO: 2, or iii) a peptide consisting of the sequence of SEQ ID NO: 3.