Preparation process of rapidly disintegrable forms for release of active substances in the buccal cavity or in body cavities administration.

摘要

Process for making a flat oral administration form decays or melts rapidly in aqueous medium, releasing active substances in the buccal cavity and orifice or body cavity and containing a matrix formed of one or more water-soluble polymers as base substances, comprising at least one active ingredient and the polymer matrix having voids or cavities whose content differs from the array as to their state of aggregation, characterized by comprising the following steps: a) preparing a solution or dispersion containing at least one polymer water soluble film former and at least one active ingredient; b) foaming of the solution or dispersion by expansion of a dissolved gas, previously adding, if necessary, a foam stabilizing agent; c) extension of the solution or dispersion on a substrate; d) solidification by drying and solvent extraction of the film containing cavities.