Procedures for preparing synthetic derivatives dibencilbutirolactónicos lignans having antichagas properties.

摘要

Process to obtain the synthetic lignane derivative hinokinin, comprising the following steps: a) reaction cubebin with PCC in dry dichloromethane, under inert atmosphere (N 2) for 24 hours at a temperature of about -6 ° C with stirring constant; b) chromatographic analysis to follow the reaction; c) isolating hinokinin (6) by: 1) pouring the reaction medium in a chromatographic column (under vacuum) with sintered plate # 2 containing MgSO 4 monohydrate and providing vacuum filtration, 2) subjecting the sample to a chromatographic column with silica gel 60 and the gradient system following solvents: 100% hexane, hexane: ethyl acetate 8: 2, hexane: ethyl acetate 7: 3, hexane: ethyl acetate 6: 4, 100% of ethyl acetate and 100% methanol; d) transfer of the organic phase to a flask collection, followed by purification by preparative circular chromatography [CCP] (Chromatotron)