USE OF GELATIN AND A RETICULATING AGENT TO PRODUCE A THERAPEUTIC RETICULATING COMPOSITION.

摘要

Use of gelatin and transglutaminase for the preparation of a cross-linking therapeutic composition for the treatment of lesions of the intervertebral disc or meniscus, the composition forming a cross-linked gelatin gel as a cellular matrix in a target area of the human or animal body, where (i) gelatin and transglutaminase are mixed together for the formation of the therapeutic crosslinking composition which is then administered to the target zone; or (ii) gelatin and transglutaminase are prepared separately from each other and administered simultaneously or consecutively in the target zone under formation of the cross-linking therapeutic composition, the target zone being Nucleus pulposus and / or Annulus fibrosus de an intervertebral disc or a meniscus, and the composition comprising intervertebral disc cells, chondrocytes and / or mesenchymal stem cells.