MULTIVALENT BOVINE CORONAVIRUS VACCINE AND METHOD OF TREATING BOVINE CORONAVIRUS INFECTION

摘要

New purified and isolated bovine coronavirus (BCV) types (II and III) aredescribed which can be used to create new modified live vaccines foradministration to cattle in order to confer immunity against virulent wild-type bovine coronavirus infection. Preferably, a multivalent modified livevaccine is provided for oral-nasal administration which includes the knownType I virus and the new Types II and III virus. Hygromycin B has alsodemonstrated to be effective for suppressing replication of the majority ofBCV isolates tested and thus can be administered to cattle as a treatment forthe chronic disease and to suppress shedding of hygromycin B-sensitive BCV incattle feces.