COMPOUNDS AND METHODS FOR THE TREATMENT OF AIRWAY DISEASES AND FOR THE DELIVERY OF AIRWAY DRUGS

摘要

Chronic obstructive airway diseases are treated by administering anosmotically active compound such as a salt, sugar, sugar alcohol, or organicosmolyte to the afflicted airway surface. The compound may be administered asa liquid or dry powder aerosol formulation. Diseases that can be treated bythe method include cystic fibrosis, chronic bronchitis, and ciliarydyskinesia. The formulations of the invention can also be used in conjunctionwith other active agents such as bronchodilators, sodium channel blockers,antibiotics, enzymes, or purinoceptor agonists on airway surfaces.