THE COMBINATION OF ANTIMICROBIAL AGENTS AND BACTERIAL INTERFERENCE TO COAT MEDICAL DEVICES

摘要

This invention relates to a method for coating a medical device comprising thesteps of applying to at least a portion of the surface of said medical device,an antimicrobial coating layer and a non-pathogenic bacterial coating layer,wherein the antimicrobial and non-pathogenic bacterial coating layers inhibitthe growth of pathogenic bacterial and fungal organisms. The non-pathogenicbacterium used in the bacterial coating layer is resistant to theantimicrobial agent. Furthermore, the non-pathogenic bacterium layer includesat least one of the following: viable whole cells, non-viable whole cells, orcellular structures or extracts. The antimicrobial agent and non-pathogenicbacterium are used to develop a kit comprising these compositions in onecontainer or in separate containers. The kit is used to coat a catheter priorto implantation in a mammal.