4-(BENZYLIDENEAMINO)-3-(METHYLSULFANYL)-4H-1,2,4-TRIAZIN-5-ONE DERIVATIVES HAVING A PDE IV-INHIBITING AND TNF-ANTAGONISTIC ACTION FOR THE TREATMENT OF HEART DISEASES AND ALLERGIES

摘要

The invention relates to triazine derivatives of formula (I), and thephysiologically compatible salts and solvates thereof, wherein R1, R2, A andR5 have the designations cited in claim 1. Said derivatives exhibit aphosphodiesterase IV-inhibiting action and can be used for the treatment ofallergic diseases, asthma, chronic bronchitis, atopic dermatitis, psoriasisand other skin diseases, inflammatory diseases, auto-immune diseases such asrheumatoid arthritis, multiple sclerosis, Crohn's disease, pancreatic diabetesor ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia,tumour growth or tumour metastases, sepsis, memory defects, arteriosclerosisand AIDS. Said derivatives can also be used to inhibit the formation of TNF.alpha..