NEW USE OF CYCLOLIGNANS AND NEW CYCLOLIGNANS

摘要

The invention refers to new compounds and the use thereof as well as the useof known cyclolignans having a trans configuration of the lactone ring asinhibitors of the insulin-like growth factor-1 receptor. Said compounds can beused for treatment of IGF-1R dependent diseases, especially cancer. Especiallydeoxypodophyllotoxin can be used for treatment of leukemia in humans.