GENTLE-ACTING SKIN-DISINFECTANTS AND HYDROALCOHOLIC GEL FORMULATIONS

摘要

Antimicrobial compositions having synergistic combinations of octoxyglycerinand at least one other antimicrobial agent in formulations which are moreeffective than prior art compositions without causing increased irritation tothe skin of the average user. In certain embodiments, skin irritation may beminimized by low concentrations of antimicrobials and/or the presence ofsoothing compounds such as zinc. Preferred embodiments include combinations ofoctoxyglycerin, a quaternary compound, and at least one other antimicrobialagent. Without being bound to any particular theory, it is hypothesized thatthe unexpected antimicrobial effectiveness of combinations of octoxyglycerinmay result from an enhancement of the permeability of microbes toantimicrobials caused by octoxyglycerin. Hydroalcoholic gel compositioncontaining alcohol, water, hydrogel, and emollient or emulsifier, wherein thecomposition has a viscosity of below 2000 centipoises at between 20 and 40 ~C.This skin-friendly hydroalcoholic gel composition, which can be furthercombined with silicone polymer, emollient solvent, thickening agent andantimicrobial agent, enhances rapid and long-term antimicrobial efficacy.