COMPOUNDS THAT ABROGATE DNA-DAMAGE-INDUCED CELL CYCLE G2 CHECKPOINT AND/OR AUGMENT THE ANTI-CANCER ACTIVITY OF DNA-DAMAGING TREATMENTS

摘要

The invention provides compositions and methods to inhibit the cell cycle G2checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammaliancells including human cells. Specifically, the invention provides compositionsand methods to sensitize cells to DNA-damaging agents by abrogating the cellcycle G2 checkpoint. Compounds of the invention are used to treatProliferative disorders such as cancer. The invention provides compositionsand methods for selectively sensitizing G1 checkpoint impaired cancer cells toDNA-damaging agents and treatments.