METHOD FOR DIAGNOSING AND MONITORING CARDIAC ISCHEMIA IN PATIENTS WITH ACUTE CHEST PAIN AND WITHOUT MYOCARDIAL INFARCTION

摘要

The present invention relates to a method for diagnosing the ischemic state in a subject who suffers from acute coronary syndrome and but not fulfilling the diagnostic criteria for a myocardial infarction. Moreover, the present invention relates to a method for identifying a subject being susceptible to cardiac intervention, wherein the subject suffers from acute coronary syndrome but not fulfilling the diagnostic criteria for a myocardial infarction. The methods of the present invention are based on the determination of fms-like tyrosine kinase-1 1 (sFLT-1) and, optionally, hepatocyte growth factor (HGF) in a sample of said subject and comparing the amount of sFLT-1 and, optionally, HGF to reference amounts. Also comprised by the present invention are kits or devices to carry out the methods of the present invention.