AGONISTS OF TLR4 AND 9 RECEPTORS FOR PREVENTING SEPTIC COMPLICATIONS OF POST-TRAUMATIC IMMUNE DEPRESSION IN PATIENTS HOSPITALIZED FOR SEVERE TRAUMA

摘要

The present invention relates to a pharmaceutical composition comprising at least one agonist of at least one ToII receptor (TLR) selected from TLRs 4 and 9, for its use in the prophylactic treatment of septic complications of post-traumatic systemic immunodepression. in a patient who has suffered one or more severe trauma, hospitalized, particularly in a hospital intensive care unit. Preferably, said TLR agonist 4 is monophosphoryl lipid A (MPLA) or deacylated 3-0 monophosphoryl lipid A (3D-MPLA) and said TLR agonist 9 is a CpG oligodeoxynucleotide (CpG ODN).