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AGONISTS OF TLR4 AND 9 RECEPTORS FOR PREVENTING SEPTIC COMPLICATIONS OF POST-TRAUMATIC IMMUNE DEPRESSION IN PATIENTS HOSPITALIZED FOR SEVERE TRAUMA
AGONISTS OF TLR4 AND 9 RECEPTORS FOR PREVENTING SEPTIC COMPLICATIONS OF POST-TRAUMATIC IMMUNE DEPRESSION IN PATIENTS HOSPITALIZED FOR SEVERE TRAUMA
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机译:TLR4和9受体的激动剂用于预防严重创伤住院患者的创伤后免疫抑郁症的并发症
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摘要
The present invention concerns a pharmaceutical composition comprising at least one agonist of at least one Toll Like receptor (TLR) chosen from TLR 4 and 9, for use in the prophylactic treatment of septic complications of post-traumatic systemic immunodepression in a patient who has suffered one or more severe traumatic injuries and is hospitalized in particular in an intensive care unit. Preferably, said TLR 4 agonist is monophosphoryl lipid A (MPLA) or deacylated 3-O-monophosphoryl lipid A (3D-MPLA) and said TLR 9 agonist is a CpG oligodeoxynucleotide (CpG ODN).
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