Construct comprising recognition domain of antibody against von Willebrand factor-specific cleaving enzyme

摘要

It is intended to provide an epitope recognized by an antibody (hereinafter referred to as anti-ADAMTS-13 antibody in some cases) against an enzyme (hereinafter referred to as ADAMTS-13 in some cases) specifically cleaving von Willebrand factor (hereinafter referred to as vWF in some cases), and a polypeptide containing this epitope domain. A polypeptide located at from the 449- to 687-positions in the amino acid sequences constituting ADAMTS-13 which is recognized by the anti-ADAMTS-13 antibody or a peptide fragment originating in this polypeptide.