Improvement of the bioavailability of active substances having an amidine function in medicaments

摘要

The invention relates to the use of N,N'-dihydroxyamidine (I), N,N'-dihydroxyamidineether (II), N,N'-dihydroxyamidine diether (III), N,N'-dihydroxyamidineester (IV), N,N'-dihydroxyamidine diester (V) or 4-hydroxy-1,2,4-oxadiazoline(VI) of the formulae cited above, wherein R represents hydrogen, an alkyl and/oraryl radical, as a substitute for an amidine function of a medicament for improvingthe bioavailability of the medicament.