Method for producing a three-dimensional macroporous filament construct based on phase inversion and construct thereby obtained

摘要

The present invention relates to a method for producing a three-dimensionalmacroporous filament construct comprising interconnected microporous filamentsshowing a suitable surface roughness and microporosity. The method comprisesthe steps of: a) preparing a suspension comprising particles of a predeterminedmaterial, a liquid solvent, one or more binders and optionally one or more dispersants,b) depositing said suspension in the form of filaments in a predetermined three-dimensional pattern, preferably in a non-solvent environment, thereby creatinga three-dimensional filament-based porous structure, c) inducing phase inversion,whereby said filaments are transformed from a liquid to a solid state, by exposingsaid filaments during the deposition of the filaments with a non-solvent vapourand to a liquid non-solvent, d) thermally treating the structure of step d) bycalcining and sintering said structure. The invention further provides a three-dimensionalmacroporous filament construct comprising interconnected microporous filamentsshowing a specific surface roughness and microporosity. The invention alsorelates to various uses of the construct, including its use for the manufactureof a biomedical product, such as a synthetic bone implant or bone graft.