Combination of photodynamic therapy and anti-VEGF agents in the treatment of unwanted choroidal neovasculature

摘要

The use of a combination of photodynamic therapy and an anti-VEGF agent in the treatment of conditions characterized by unwanted choroidal neovasculature is described. These conditions include wet age-related macular degeneration Preferred anti-VEGF agents are antibodies such as bevacizumab or ranibizumab Photosensitizers may be selected from green porphyrins such as BPD-MA (verteporfin) and the photodynamic activation of the photosensitizer may be accomplished using a reduced fluence rate. The use may further comprises an anti-inflammatory agent such a dexamethasone.