Coated tablets of 6-(5-chloro-2-pyridyl) -5- (4-methyl-1-piperazinyl) carbonyloxy-7-oxo-6, 7-dihydro-5H-pyrrol o 3,4-b pyrazine and methods for measuring effectiveness of coating

摘要

Coated tablets of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1- piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided. The tablets minimize the perceived bitterness of the medicament. A method for analyzing instantaneous dissolution of sub-microgram quantities of core material is also disclosed.