SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION

摘要

Compounds according to the invention are 2-(3-Q⁵-4-Q⁴-5-Q³-thien-2-yl)-4-R³-5-R²-1,3-thiazol, 2-(3-Q⁵-4-Q⁴- 5-Q³-fur-2-yl)-4-R³-5-R²-1,3-thiazol, 2-(3-Q⁵-4-Q⁴-5-Q³-thien-2-yl)-5-R²-1,3,4-thiadiazol, 2-(3-Q⁵-4-Q⁴-5-Q³-fur-2-yl)-5-R²-1,3,4-thiadiazol, 2-(2-Q³-4-Q⁵-1,3-thiazol-5-yl)4-R³-5-R²-1,3-thiazol, 2-(2-Q³-4-Q⁵-1,3-oxazol-5-yl)4- R³-5-R²-1,3-thiazol, 2-(4-Q⁴-5-Q³-1,3-thiazol-2-yl)4-R³-5-R²-1,3-thiazol, 2-(4-Q⁴-5-Q³-1,3-oxazol-2-yl)4-R³-5- R²-1,3-thiazol, 2-(4-Q⁵-5-Q⁴-3-Q²-thien-3-yl)4-R³-5-R²-1,3-thiazol, 2-(4-Q⁵-5-Q⁴-3-Q²-fur-3-yl)4-R³-5-R²-1,3-thiazol, 2-benzo[b]thiophen-2-yl4-R³-5-R²-1,3-thiazol, 2-benzo[b]furan-2-yl4-R³-5-R²-1,3-thiazol, 2-(3-Q⁵-4- Q⁴-5-Q³-thien-2-yl)-6-Z²-1,3-benzo[d]thiazol, 2-(3-Q⁵-4-Q⁴-5-Q³-thien-2-yl)-6-Z²-1,3-benzo[d]oxazol, 2-(2-Z⁵-3- Z⁶-4-Z⁷-phenyl)4-R³-5-R²-1,3-thiazol, 2-(5-Z⁸-6-Z⁷-3-pyridyl)4-R³-5-R²-1,3-thiazol, 2-(3-R³-4-R²-phenyl)-3-Q⁵- 4-Q⁴-5-Q³-thiophen, 2-(3-R³-4-R²-phenyl)-3-Q⁵-4-Q⁴-5-Q³-furan, N-Z⁹-N-(4-R³-5-R²-1,3-thiazol-2-yl)-3-Q⁵-4-Q⁴- 5-Q³-thien-2-yl-carboxamid, N-Z⁹-N-(4-R³-5-R²-1,3-thiazol-2-yl)-3-Q⁵-4-Q⁴-5-Q³-fur-2-yl-carboxamid, 5-(3-Q⁵-4- Q⁴-5-Q³-thien-2-yl)4-R⁴-2-R²-1,3-thiazol, 5-(3-Q⁵-4-Q⁴-5-Q³-fur-2-yl)4-R⁴-2-R²-1,3-thiazol, 2-(3-Q⁵-4-Q⁴-5-Q³- thien-2-yl)-3-R⁴-4-R³-5-R²-thiophen, 2-(3-Q⁵-4-Q⁴-5-Q³-fur-2-yl)-3-R⁴-4-R³-5-R²-thiophen; wherein R², R^3, R⁴, Q², Q³, Q⁴, Q⁵, Z², Z⁵, Z⁶, Z⁷, Z⁸ and Z⁹ are as defined in the description. Said compounds are particularly advantageous for treating and/or preventing influenza type A and/or influenza type B infections in humans, mammals and/or birds, and for treating and/or preventing respiratory syncytial virus infections in humans, mammals and/or birds.