首页> 外国专利> 2-CYCLOAMINO-5-(PYRIDIN-4-YL)IMIDAZO2,1-B1,3,4THIADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF

2-CYCLOAMINO-5-(PYRIDIN-4-YL)IMIDAZO2,1-B1,3,4THIADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF

机译：2-环氯氨基-5-（吡啶-4-基）咪唑并[2,1- B ] [1,3,4]噻二唑衍生物，其制备和治疗用途

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摘要

The invention relates to 2-cycloamino-5-(pyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazole derivatives of the general formula (I) where: R5 is a hydrogen atom or a C_1-3 alkyl, -NR₇R₈, or C_1-3 alkyloxy group; R6 is an optionally substituted phenyl group; A is a C_1-7-alklene group optionally substituted by one or two R_a groups; B is a C_1-7-alkylene group optionally substituted by an R_b group; L is a nitrogen atom optionally substituted by an R_c or R_d group, or a carbon atom substituted by a Rei group and a R_d group or two R_e2 groups; R₇ and R₈ are independently a hydrogen atom or a C_1-3 alkyl group. The invention also relates to a method for preparing same and to the therapeutic use thereof. 展开▼

机译：本发明涉及通式（I）的2-环氨基-5-（吡啶-4-基）咪唑并[2,1- b ] [1,3,4]噻二唑衍生物，其中： R5是氢原子或C _{1-3 烷基，-NR _{7 R _{8 或C _{1-3 烷氧基; R6是任选取代的苯基; A为任选被一个或两个R _{a 基团取代的C _{1-7 -烯基; B是任选地被R _{b 基团取代的C _{1-7 -亚烷基; L是被R _{c 或R _{d 基团任选取代的氮原子，或被Rei基和R _{d 基团取代的碳原子。组或两个R _{e2 组; R _{7 和R _{8 独立地是氢原子或C _{1-3 烷基。本发明还涉及其制备方法及其治疗用途。}}}}}}}}}}}}}}} 展开▼

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公开/公告号WO2010130934A3

专利类型

公开/公告日2011-01-06

原文格式PDF

申请/专利权人 SANOFI-AVENTIS;OUDOT ROMAIN;PACAUD CHRISTOPHE;PUECH FREDERIC;
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申请/专利号WO2010FR50897

发明设计人 OUDOT ROMAIN;PACAUD CHRISTOPHE;PUECH FREDERIC;
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申请日2010-05-10

分类号C07D513/06;A61K31/496;A61K31/433;A61K31/4439;A61P35;A61P29;A61P25;

国家 WO

入库时间 2022-08-21 18:00:36

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