首页>
外国专利>
AN IMPROVED METHOD FOR DIAGNOSING OR PREDICTING SHORT STATURE IN HUMANS
AN IMPROVED METHOD FOR DIAGNOSING OR PREDICTING SHORT STATURE IN HUMANS
展开▼
机译:诊断或预测人的短身的改进方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
An improved assay for measuring the release of endogenous growth hormone (GH) is described. The method focuses on determining the presence of an immediate release pool (IRP) of GH, and the extent to which it is rapidly discharged into the circulation of humans, including children. A larger and less labile pool responds continuously to long term stimulation. The method considers that determining the ten minute AUC measurement, i.e., ten minutes after induction of GH release by administering growth hormone releasing hormone (GHRH) will reveal an immediate release pool of GH. As further disclosed herein, the IRP of GH has a higher correlation with peak GH release than the conventional 120 minute time point. Further the AUC10 correlates with height standard deviation measurements whereas the AUC120 does not.
展开▼