COMPOSITIONS AND METHODS FOR DIAGNOSING THE OCCURRENCE OR LIKELIHOOD OF OCCURRENCE OF TESTICULAR GERM CELL CANCER

摘要

A diagnostic composition useful for diagnosing testicular germ cell cancer or tumors or for providing an assessment of the susceptibility of a subject to this cancer includes at least one reagent capable of identifying a genetic variant of the KITLG gene or in the KITLG genomic region or of the SPRY4 gene or of the SPRY4 genomic region. The variant is associated with susceptibility of a human subject to testicular germ cell cancer or tumors. Methods of diagnosis include identifying such genetic variants in a biological sample of a male subject. These variants include one or more single nucleotide polymorphisms (SNP) identified within certain genomic marker sequences of previously unknown function.