USE OF INHIBITORS OF DIPEPTIDYPEPTIDASE IV (EC 3.3.14.5) AND AMINOPEPTIDASE N (EC 3.4.11.2) FOR THE TREATMENT OF NEURODEGENERATION INDUCED BY ISCHAEMIA

摘要

The invention relates to a method which reduces or prevents lesions to cerebral tissues after ischaemia or brain/cerebral traumas, involving the separate or combined administration and effect of enzyme inhibitors of alanyl-aminopeptidase (APN) and dipeptidylpeptidase IV (DP IV) or enzymes having the same similar substrate specificity. The invention demonstrates that in order to prevent or treat the above-mentioned indications, the separate or combined application of inhibitors of the above-mentioned enzymes or corresponding preparations and forms of administration are suitable.