首页> 外国专利> DETECTION OF DIGESTIVE SYSTEM CANCER, STOMACH CANCER, COLON CANCER, PANCREATIC CANCER, AND BILIARY TRACT CANCER BY MEANS OF GENE EXPRESSION PROFILING

DETECTION OF DIGESTIVE SYSTEM CANCER, STOMACH CANCER, COLON CANCER, PANCREATIC CANCER, AND BILIARY TRACT CANCER BY MEANS OF GENE EXPRESSION PROFILING

机译:基因表达谱分析检测消化系统癌,胃癌,结肠癌,胰腺癌和胆道癌

摘要

Disclosed are a method and a reagent for detecting, in peripheral blood, patients suffering from digestive system cancer, stomach cancer, colon cancer, pancreatic cancer, or biliary tract cancer by analyzing genes that have a change in expression in digestive system cancer, stomach cancer, colon cancer, pancreatic cancer, or biliary tract cancer cases in comparison to a healthy individual. Specifically disclosed are a method for obtaining at least one gene expression profile selected from a group that comprises probes corresponding to genes that have a change in expression in digestive system cancer, stomach cancer, colon cancer, pancreatic cancer, or biliary tract cancer cases in comparison to a healthy individual, to detect, in peripheral blood, patients suffering from digestive system cancer, stomach cancer, colon cancer, pancreatic cancer, or biliary tract cancer on the basis of the expression profile; and a reagent for detecting digestive system cancer, stomach cancer, colon cancer, pancreatic cancer, or biliary tract cancer that includes either nucleotides comprising at least one gene base sequence selected from a group that comprises probes having a change in expression in digestive system cancer, stomach cancer, colon cancer, pancreatic cancer, or biliary tract cancer, or nucleotides that include a partial sequence thereof or a complementary sequence of each.
机译:公开了一种通过分析在消化系统癌,胃癌中表达改变的基因,在外周血中检测患有消化系统癌,胃癌,结肠癌,胰腺癌或胆道癌的患者的方法和试剂。与健康个体相比,结肠癌,胰腺癌或胆道癌病例。具体地公开了一种用于获得至少一个基因表达谱的方法,所述基因表达谱选自:与对应于在消化系统癌,胃癌,结肠癌,胰腺癌或胆道癌病例中表达改变的基因相对应的探针的组。对于健康个体,根据表达谱在外周血中检测患有消化系统癌症,胃癌,结肠癌,胰腺癌或胆道癌的患者;以及用于检测消化系统癌,胃癌,结肠癌,胰腺癌或胆道癌的试剂,其包含含有至少一种基因碱基序列的核苷酸,所述至少一种基因碱基序列选自包含在消化系统癌中表达变化的探针的组,胃癌,结肠癌,胰腺癌或胆道癌,或包括其部分序列或每种序列的互补序列的核苷酸。

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