CHIMERIC HUMAN GROWTH HORMONE DERIVED FROM THE PLACENTA AND PITUITARY ISOFORM AND PROCESSES FOR OBTAINING SAID CHIMERA

摘要

A way to increase the production of recombinant polypeptides by combining pieces of several different isoforms of a given gene to make a chimeric isoform of the gene (using a chimeric gene can increase the production of polypeptide over 25%), or by inserting several copies of the coding region in tandem into a transformation vector (e.g., plasmids carrying multiple copies of the chimera of SEQ ID NO: 3 increased production 107%).