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ASSAY FOR INHIBITORS OF SUMO AND SUMO-TARGETED UBIQUITIN LIGASE PATHWAY
ASSAY FOR INHIBITORS OF SUMO AND SUMO-TARGETED UBIQUITIN LIGASE PATHWAY
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机译:相扑抑制剂和相扑靶泛泛素连接酶途径的抑制剂检测
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摘要
The present invention provides a method for determining a putative agent that inhibits the SUMO or the SUMO-targeted ubiquitin ligase pathway comprising the steps of contacting mutant MOT1 cells with the putative agent under conditions (1) permitting mutant MOT1 cell growth in the presence of a SUMO or SUMO-targeted ubiquitin ligase pathway inhibitor and (2) not permitting mutant MOT1 cell growth in the absence of a SUMO or SUMO-targeted ubiquitin ligase pathway inhibitor, and measuring cell growth.
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