MANUFACTURE OF EXTRACELLULAR MATRIX PRODUCTS USING SUPERCRITICAL OR NEAR SUPERCRITICAL FLUIDS

摘要

Described are methods for preparing extracellular matrix materials using treatment with a fluid under conditions at which the fluid is at least substantially supercritical. Preferred prepared extracellular matrix materials beneficially retain endogenous bioactive molecules and/or beneficial native mechanical properties even after treatment with the fluid. Also described are materials that can be prepared by such methods, and uses of such materials.