MODULATION OF RE1 SILENCING TRANSCRIPTION FACTOR EXPRESSION

摘要

Disclosed herein are antisense compounds and methods for decreasing REST expression. Also disclosed herein are methods for increasing DMN1, BDNF, and synapsin1 expression by decreasing REST expression with antisense compounds. Methods of treating or preventing Huntington's Disease in an individual in need thereof by decreasing REST expression and/or increasing DMN1, BDNF, and synapsin1 expression are described herein.