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REPROGRAMMING BLOOD CELLS TO PLURIPOTENT AND MULTIPOTENT STEM CELLS
REPROGRAMMING BLOOD CELLS TO PLURIPOTENT AND MULTIPOTENT STEM CELLS
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机译:将血液细胞重编程为多潜能和多潜能干细胞
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摘要
The present invention is based on the seminal discovery that cord blood (CB) and adult bone marrow (BM) CD34+ cells can be reprogrammed to early stem cells. The invention provides the reprogramming of CB and adult bone marrow (BM) CD34+ cells from subjects without any pre-treatment. Provided are methods for reprogramming blood cells of a subject. Also provided are methods of disease modeling and methods of generating subject- specific differentiated cells. In addition, the invention provides methods of identifying an agent that alters a function of subject-specific differentiated cells as well as isolated pluripotent or multipotent stem cells reprogrammed from blood cells.
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