Adam12 as marker for fetal Turner Syndrome

摘要

The present invention provides a method and an assay for providing an indication of fetal Tuner Syndrome..;The present inventors for the first time demonstrate that ADAM12 is an important indicator of fetal chromosomal disease and placenta function. Specifically ADAM12 is a good marker for e.g. Downs's syndrome, trisomy 18, preeclampsia, Turner syndrome in both first and second trimester.;It is an object of the invention to provide an improvement of the existing marker tests that exhibits a decreased false positive rate.