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RETROGRADE TRANSPORT OF SIRNA AND THERAPEUTIC USES TO TREAT NEUROLOGIC DISORDERS
RETROGRADE TRANSPORT OF SIRNA AND THERAPEUTIC USES TO TREAT NEUROLOGIC DISORDERS
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机译:siRNA的逆向转运及其治疗神经疾病的用途。
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摘要
Methods of treating disorders affecting the central nervous system (CNS) are disclosed. More particularly, methods of treating neurological disorders are disclosed which show therapeutic or prophylactic treatment of a mammalian CNS disorder by effecting local administration of an iRNA agent, followed by retrograde transport of the iRNA agent away from the administration site and onto multiple regions within the CNS. This retrograde transport of iRNA results in an improved therapeutic involvement for the respective iRNA agent.
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