Design of Dendrimer-Based System for Delivery of Therapeutic SiRNA for Treating Cardiac Disease

摘要

In this study, oligo arginine modified f-PAMAM-PEG-R9 has shown higher siRNA delivery efficiency in cardiomyocytes (CMs) than unmodified or TAT modified materials, which may be attributed to the preference of CMs to oligo arginine and also the smaller size of siRNA loaded particles formed by this material. AT2R is another important receptor of Ang Ⅱ, and it is generally considered as a protective receptor in IR injury, so the up-regulation of AT2R by AT1R knockdown may bring additional beneficial effects. According to the EF data, empty dendrimeric material didn't worsen cardiac function, implying the PEG segment and degradable design might have successfully kept dendrimeric materials biocompatible.