NONHUMAN ANIMAL MODEL OF TYPE 2 DIABETES

摘要

Provided is a novel nonhuman animal model of type 2 diabetes which spontaneously causes a pathology similar to nonobese type 2 diabetes common among Japanese people, wherein the function of the Cdkal1 gene is specifically suppressed on the chromosome of the pancreas β cell. Specifically, the nonhuman animal model of type 2 diabetes may be prepared by mating: a nonhuman animal having a site-specific recombinase-recognition sequence on the 3'-untranslated region and the 5'-untranslated region of a predetermined region containing one or more exons in the Cdkal1 gene; and a nonhuman animal in which a site-specific recombinase gene which recognizes the aforementioned site-specific recombinase-recognition sequence, and can cutout the aforementioned predetermined region is inserted in a manner so as to be able to express on the downstream of the promoter of a gene that specifically expresses in the pancreas.