首页> 外国专利> BLOCKING THE MIGRATION OR METASTASIS OF CANCER CELLS BY AFFECTING ADHESION PROTEINS AND THE USES OF NEW COMPOUNDS THEREOF

BLOCKING THE MIGRATION OR METASTASIS OF CANCER CELLS BY AFFECTING ADHESION PROTEINS AND THE USES OF NEW COMPOUNDS THEREOF

机译:通过影响粘附蛋白及其新化合物的使用来阻止癌细胞的迁移或转移

摘要

This invention provides methods, processes, compounds and compositions for modulating the gene expression or secretion of adhesion proteins or their receptors to cure disease, wherein the modulating comprises positive and negative regulating; wherein comprises inhibiting cancer growth, wherein the adhesion proteins or receptors comprise fibronectin, integrins family, Myosin, vitronectin, collagen, laminin, Glycosylation cell surface proteins, polyglycans, cadherin, heparin, tenascin, CD 54, CAM, elastin and FAK; wherein the methods, processes, compounds and compositions are also for anti-angiogenesis; wherein the cancers comprise breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, CNS cancer, melanoma cancer, renal cancer or cervix cancer.
机译:本发明提供了调节粘附蛋白或其受体的基因表达或分泌以治愈疾病的方法,方法,化合物和组合物,其中所述调节包括正调节和负调节;其中包括抑制癌症的生长,其中粘附蛋白或受体包括纤连蛋白,整联蛋白家族,肌球蛋白,玻连蛋白,胶原蛋白,层粘连蛋白,糖基化细胞表面蛋白,多糖,钙粘蛋白,肝素,肌腱蛋白,CD 54,CAM,弹性蛋白和FAK;其中所述方法,方法,化合物和组合物也用于抗血管生成;其中所述癌症包括乳腺癌,白细胞癌,肝癌,卵巢癌,膀胱癌,前列腺癌,皮肤癌,骨癌,脑癌,白血病,肺癌,结肠癌,CNS癌,黑素瘤癌,肾癌或宫颈癌癌症。

著录项

  • 公开/公告号EP2121715A4

    专利类型

  • 公开/公告日2010-12-29

    原文格式PDF

  • 申请/专利权人 PACIFIC ARROW LIMITED;

    申请/专利号EP20080725693

  • 发明设计人 CHAN PUI-KWONG;MAK MAY SUNG;

    申请日2008-02-15

  • 分类号A61K31/704;A61P35;

  • 国家 EP

  • 入库时间 2022-08-21 17:57:34

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