METABOLOMIC BIOMARKER SIGNATURE OF PRE-ECLAMPSIA RISK

摘要

The invention provides a panel of metabolites that are associated with early detection of predisposition to pre-eclampsia. In some embodiments, the risk may be detected early in pregnancy, for example at 15 weeks gestation, by measuring the level of selected compounds in maternal serum. The compound may be one or more of 5-hydroxytryptophan, a monosaccharide, decanoylcarnitine, methylglutaric acid, adipic acid, oleic acid, docosahexaenoic acid, docosatriynoic acid, y-butyrolactone, oxolan-3-one, 2-oxovaleric acid, oxo-methylbutanoic acid, acetoacetic acid, hexadecenoyl-eicosatetraenoyl-sn-glycerol, Di-(octadecadienoyl)-sn-glycerol, sphingosine 1- phosphate, sphinganine 1-phosphate or a vitamin D3 meabolite.