Determination of level of immunoglobulin fragmentation or modification and use of a trypsin inhibitor for preventing the same

摘要

The invention provides a trypsin inhibitor for use in a method of treating or preventing a disorder associated with elevated trypsin activity which is correlated with IgG fragmentation or modification. The invention also provides a method for determining the risk of an individual of suffering from inflammation, opportunistic infection or disruption of immunoglobulin metabolism, comprising (a) determining the level of fragmentation or modification of Fc function of immunoglobulins in a sample taken from the individual and (b) determining thereby the risk of inflammation, impaired immune response or opportunistic infection.